Sex Differences in the Relation Between Frailty and Endothelial Dysfunction in Old Mice.

ABSTRACT: Vascular endothelial function declines with age on average, but there is high variability in the magnitude of this decline within populations. Measurements of frailty, known as frailty index (FI), can be used as surrogates for biological age, but it is unknown if frailty relates to the age-related decline in vascular function. To examine this relation, we studied young (4-9 months) and old (23-32 months) C57BL6 mice of both sexes. We found that FI was greater in old compared with young mice, but did not differ between old male and female mice. Middle cerebral artery (MCA) and mesenteric artery endothelium-dependent dilation (EDD) also did not differ between old male and female mice; however, there were sex differences in the relations between FI and EDD. For the MCA, FI was inversely relat

SUBMITTER: Cole JA 

PROVIDER: S-EPMC8893262 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature