An HDAC9-associated immune-related signature predicts bladder cancer prognosis.

ABSTRACT:

Background

The close relationship between histone deacetylase 9 (HDAC9) and immunity has attracted attention. We constructed an immune signature for HDAC9, a vital epigenetic modification, to predict the survival status and treatment benefits in bladder cancer (BC).

Methods

An exhaustive analysis of HDAC9 and immunology via the tumor and immune system interaction database (TISIDB) was performed, and an immune prognostic risk signature was developed based on genes enriched in the top five immune-related pathways under high HDAC9 status. Comprehensive analysis of survival curves and Cox regression were used to estimate the effectiveness of the risk signature. The relationship between immunological characteristics and the risk score was evaluated, and the mechanisms were also e

SUBMITTER: Fu Y 

PROVIDER: S-EPMC8893690 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature