Protective Effects of Alternanthera sessilis Ethanolic Extract against TNF-α or H₂O₂-Induced Endothelial Activation in Human Aortic Endothelial Cells.

ABSTRACT: Activation of the endothelium has been shown to contribute to the early stage of vascular diseases such as atherosclerosis and hypertension. In endothelial activation, excess reactive oxygen species (ROS) production and increased expression of cell adhesion molecules cause an increase in vascular permeability. Alternanthera sessilis (L.) R. Br. is an edible traditional herbal plant, which has previously been shown to possess antioxidant and anti-inflammatory effects. However, the effect of A. sessilis on the activation of human aortic endothelial cells (HAECs) remains unknown. This study aimed to investigate the effects of A. sessilis on endothelial permeability, vascular cell adhesion-1 (VCAM-1) expression, production of ROS and hydrogen peroxide (H₂O₂

SUBMITTER: Mohd Razali NN 

PROVIDER: S-EPMC8894009 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature