Different glomerular filtration rate estimating formula for prescribing DOACs in oldest patients: appropriate dosage and bleeding risk. Post hoc analysis of a prospective cohort.

ABSTRACT:

Background

Direct oral anticoagulants (DOACs) pharmacokinetics depends on estimated glomerular filtration rate (eGFR), whose estimation is crucial for optimal risk/benefit balance.

Aims

To assess the concordance among different eGFR formulas and the potential impact on DOACs prescription appropriateness and bleeding risk in oldest hospitalized patients.

Methods

Post hoc analysis of a single-centre prospective cohort study. eGFR was calculated by creatinine-based (MDRD, CKD-EPI_Cr, BIS₁) and creatinine-cystatin-C-based (CKD-EPI_Comb and BIS₂) formulas. Patients were stratified according to eGFR [severely depressed (SD) 15-29; moderately depressed (MD) 30-49; preserved/mildly depressed (PMD): ≥ 50 ml/min/1.73 m²]. Con

SUBMITTER: Calsolaro V 

PROVIDER: S-EPMC8894223 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature