High PIRCHE Scores May Allow Risk Stratification of Borderline Rejection in Kidney Transplant Recipients.

ABSTRACT:

Background

The diagnosis of borderline rejection (BLR) ranges from mild inflammation to clinically significant TCMR and is associated with an increased risk of allograft dysfunction. Currently, there is no consensus regarding its treatment due in part to a lack of biomarkers to identify cases with increased risk for immune-mediated injury.

Methods

We identified 60 of 924 kidney transplant recipients (KTRs) with isolated and untreated BLR. We analyzed the impact of predicted indirectly recognizable HLA epitopes (PIRCHE) score on future rejection, de novo DSA development, and recovery to baseline allograft function. Additionally, we compared the outcomes of different Banff rejection phenotypes.

Results

Total PIRCHE scores were significantly higher in KTRs with BL

SUBMITTER: Lezoeva E 

PROVIDER: S-EPMC8894244 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature