Modeling energy depletion in rat livers using Nash equilibrium metabolic pathway analysis.

ABSTRACT: The current gold standard of Static Cold Storage (SCS), which is static cold storage on ice (about + 4 °C) in a specialized media such as the University of Wisconsin solution (UW), limits storage to few hours for vascular and metabolically active tissues such as the liver and the heart. The liver is arguably the pinnacle of metabolism in human body and therefore metabolic pathway analysis immediately becomes very relevant. In this article, a Nash Equilibrium (NE) approach, which is a first principles approach, is used to model and simulate the static cold storage and warm ischemia of a proposed model of liver cells. Simulations of energy depletion in the liver in static cold storage measured by ATP content and energy charge are presented along with comparisons to experimental data. In addi

SUBMITTER: Lucia A 

PROVIDER: S-EPMC8894355 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature