Role of mobile genetic elements in the global dissemination of the carbapenem resistance gene bla_NDM.

ABSTRACT: The mobile resistance gene bla_NDM encodes the NDM enzyme which hydrolyses carbapenems, a class of antibiotics used to treat some of the most severe bacterial infections. The bla_NDM gene is globally distributed across a variety of Gram-negative bacteria on multiple plasmids, typically located within highly recombining and transposon-rich genomic regions, which leads to the dynamics underlying the global dissemination of bla_NDM to remain poorly resolved. Here, we compile a dataset of over 6000 bacterial genomes harbouring the bla_NDM gene, including 104 newly generated PacBio hybrid assemblies from clinical and livestock-associated isolates across China. We develop a computational approach to track structural variants surrounding bla_NDM,

SUBMITTER: Acman M 

PROVIDER: S-EPMC8894482 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature