Effect of Azithromycin on the Ocular Surface Microbiome of Children in a High Prevalence Trachoma Area.

ABSTRACT:

Purpose

The aim of this study was to evaluate the effect of the 4 times per year mass azithromycin distributions on the ocular surface microbiome of children in a trachoma endemic area.

Methods

In this cluster-randomized controlled trial, children aged 1 to 10 years in rural communities in the Goncha Seso Enesie district of Ethiopia were randomized to either no treatment or treatment with a single dose of oral azithromycin (height-based dosing to approximate 20 mg/kg) every 3 months for 1 year. Post hoc analysis of ocular surface Chlamydia trachomatis load, microbial community diversity, and macrolide resistance determinants was performed to evaluate differences between treatment arms.

Results

One thousand two hundred fifty-five children from 24 communities were inclu

SUBMITTER: Doan T 

PROVIDER: S-EPMC8894504 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature