Noise sensitivity of ⁸⁹Zr-Immuno-PET radiomics based on count-reduced clinical images.

ABSTRACT:

Purpose

Low photon count in ⁸⁹Zr-Immuno-PET results in images with a low signal-to-noise ratio (SNR). Since PET radiomics are sensitive to noise, this study focuses on the impact of noise on radiomic features from ⁸⁹Zr-Immuno-PET clinical images. We hypothesise that ⁸⁹Zr-Immuno-PET derived radiomic features have: (1) noise-induced variability affecting their precision and (2) noise-induced bias affecting their accuracy. This study aims to identify those features that are not or only minimally affected by noise in terms of precision and accuracy.

Methods

Count-split ⁸⁹Zr-Immuno-PET patient scans from previous studies with three different ⁸⁹Zr-labelled monoclonal antibodies were used to extract radiomic features at 50% (S5

SUBMITTER: Somasundaram A 

PROVIDER: S-EPMC8894530 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature