Application of a VP4/VP2-inferred transmission clusters in estimating the impact of interventions on rhinovirus transmission.

ABSTRACT:

Background

Despite the clinical burden attributable to rhinovirus (RV) infections, the RV transmission dynamics and the impact of interventions on viral transmission remain elusive.

Methods

A total of 3,935 nasopharyngeal specimens were examined, from which the VP4/VP2 gene was sequenced and genotyped. RV transmission clusters were reconstructed using the genetic threshold of 0.005 substitutions/site, estimated from the global VP4/VP2 sequences. A transmission cluster is characterized by the presence of at least two individuals (represent by nodes), whose viral sequences are genetically linked (represent by undirected edges) at the estimated genetic distance threshold supported by bootstrap value of ≥ 90%. To assess the impact of facemask, pleconaril and social distancing on

SUBMITTER: Ng KT 

PROVIDER: S-EPMC8894564 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature