Azepanodipterocarpol is potential candidate for inhibits influenza H1N1 type among other lupane, oleanane, and dammarane A-ring amino-triterpenoids.

ABSTRACT: A series of lupane-, oleanane- and dammarane-based triterpenoids with 3β-amino, A-ring azepano- and 3,4-seco-fragments has been synthesized and evaluated for antiviral activity against influenza A(H1N1) virus. It was found that azepanodipterocarpol 8 and 3β-amino-28-oxoallobetulin 11 showed antiviral activity with IC₅₀ 1.1 and 2.6 μg ml^-1, and selectivity index of 19 and 10, respectively.

SUBMITTER: Smirnova I 

PROVIDER: S-EPMC8894567 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature