Role of a Urinary Biomarker in the Common Mechanism of Physical Performance and Cognitive Function.

ABSTRACT:

Introduction

Healthy aging is described as a process of developing and maintaining intrinsic abilities, including physical and cognitive functions. Although oxidative stress is a common mechanism shared by loss of muscle strength and dementia, its relationship with decreased physical performance and cognitive impairment remains unclear. We aimed to investigate the role of urinary 8-oxo-7, 8-dihydroguanosine (8-oxoGsn), a biomarker of oxidative damage to RNA, in physical and cognitive decline.

Methods

The study followed a cross-sectional design and recruited 40-94-year-old inhabitants of Beijing, China (471 men and 881 women). The physical performance of the participants was assessed using handgrip strength, walking speed, and the repeated chair stand test. The cognitive func

SUBMITTER: Jiang S 

PROVIDER: S-EPMC8894651 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature