The initial expression alterations occurring to transcription factors during the formation of breast cancer: Evidence from bioinformatics.

ABSTRACT:

Background

Breast cancer (BC) is the leading malignancy among women worldwide.

Aim

This work aimed to present a comprehensively bioinformatic analysis of gene expression profiles and to identify the hub genes during BC tumorigenesis, providing potential biomarkers and targets for the diagnosis and therapy of BC.

Materials & methods

In this study, multiple public databases, bioinformatics approaches, and online analytical tools were employed and the real-time reverse transcription polymerase chain reaction was implemented.

Results

First, we identified 10, 107, and 3869 differentially expressed genes (DEGs) from three gene expression datasets (GSE9574, GSE15852, and GSE42568, covering normal, para-cancerous, and BC samples, respectively), and investigated differe

SUBMITTER: Dong X 

PROVIDER: S-EPMC8894706 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature