BCAT1: A risk factor in multiple cancers based on a pan-cancer analysis.

ABSTRACT:

Background

Although branched chain amino acid transaminase 1 (BCAT1) has been identified to play an essential role in multiple tumors, no studies on its role in pan-cancer have been consulted before.

Methods

The study comprehensively analyzes the expression, potential mechanisms, and clinical significance of BCAT1 in pan-cancer through utilizing 16,847 samples, providing novel clues for the treatment of cancers. A Kruskal-Wallis test and the Wilcoxon rank-sum and signed-rank tests were applied to investigate diverse BCAT1 expression between various groups (e.g., cancer tissues versus normal tissues). Spearman's rank correlation coefficient was used in all correlation analyses in the study. Cox analyses and Kaplan-Meier curves were utilized to identify the prognosis significa

SUBMITTER: Li GS 

PROVIDER: S-EPMC8894718 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature