IgG Binds Escherichia coli Serine Protease EspP and Protects Mice From E. coli O157:H7 Infection.

ABSTRACT: Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administration of murine IgG on day 3, or both on day 3 and 6, post-inoculation improved survival and decreased intestinal and renal pathology. When given on both day 3 and 6 post-inoculation IgG treatment also improved kidney function in infected mice. Murine and human commercially available IgG preparations bound to proteins in culture filtrates from E. coli O157:H7. Bound proteins wer

SUBMITTER: Tontanahal A 

PROVIDER: S-EPMC8894809 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature