Unexpected Arabinosylation after Humanization of Plant Protein N-Glycosylation.

ABSTRACT: As biopharmaceuticals, recombinant proteins have become indispensable tools in medicine. An increasing demand, not only in quantity but also in diversity, drives the constant development and improvement of production platforms. The N-glycosylation pattern on biopharmaceuticals plays an important role in activity, serum half-life and immunogenicity. Therefore, production platforms with tailored protein N-glycosylation are of great interest. Plant-based systems have already demonstrated their potential to produce pharmaceutically relevant recombinant proteins, although their N-glycan patterns differ from those in humans. Plants have shown great plasticity towards the manipulation of their glycosylation machinery, and some have already been glyco-engineered in order to av

SUBMITTER: Bohlender LL 

PROVIDER: S-EPMC8894861 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature