Trends in coordination of rhenium organometallic complexes in the Protein Data Bank.

ABSTRACT: Radiopharmaceutical development has similar overall characteristics to any biomedical drug development requiring a compound's stability, aqueous solubility and selectivity to a specific disease site. However, organometallic complexes containing ^188/186Re or ^99mTc involve a d-block transition-metal radioactive isotope and therefore bring additional factors such as metal oxidation states, isotope purity and half life into play. This topical review is focused on the development of radiopharmaceuticals containing the radioisotopes of rhenium and technetium and, therefore, on the occurrence of these organometallic complexes in protein structures in the Worldwide Protein Data Bank (wwPDB). The purpose of incorporating the group 7 transition metals of rhenium/techneti

SUBMITTER: Brink A 

PROVIDER: S-EPMC8895017 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature