Bortezomib-Encapsulated Dual Responsive Copolymeric Nanoparticles for Gallbladder Cancer Targeted Therapy.

ABSTRACT: Gallbladder cancer (GBC) is a rare but the most malignant type of biliary tract tumor. It is usually diagnosed at an advanced stage and conventional treatments are unsatisfactory. As a proteasome inhibitor, bortezomib (BTZ) exhibits excellent antitumor ability in GBC. However, the long-term treatment efficacy is limited by its resistance, poor stability, and high toxicity. Herein, BTZ-encapsulated pH-responsive copolymeric nanoparticles with estrone (ES-NP_{(BTZ; Ce6)} ) for GBC-specific targeted therapy is reported. Due to the high estrogen receptor expression in GBC, ES-NP_{(BTZ; Ce6)} can rapidly enter the cells and accumulate near the nucleus via ES-mediated endocytosis. Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is g

SUBMITTER: Chen M 

PROVIDER: S-EPMC8895115 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature