Clinical Significance of Composition and Functional Diversity of the Vaginal Microbiome in Recurrent Vaginitis.

ABSTRACT:

Objective

The vaginal microbiome protects the female genital tract from various diseases, such as vaginitis, a vaginal inflammation characterized by abnormal discharge, itching, and pain. To evaluate the clinical relationship between the vaginal microbiome and the pathophysiology of recurrent vaginitis (RV), we investigated the microbiome taxonomic profile (MTP) in the vaginal samples of Korean female patients with RV.

Methods

Forty women of reproductive age diagnosed with RV were enrolled. The vaginal MTP of patients was analyzed using 16S ribosomal RNA gene sequencing, and the results were compared with that of healthy women (n = 100). Further, the association of the vaginal community state type (CST) with the clinical characteristics was analyzed.

Results

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SUBMITTER: Kim MJ 

PROVIDER: S-EPMC8895140 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature