A Guanosine-Quadruplex Hydrogel as Cascade Reaction Container Consuming Endogenous Glucose for Infected Wound Treatment-A Study in Diabetic Mice.

ABSTRACT: Diabetic foot ulcers infected with antibiotic-resistant bacteria form a severe complication of diabetes. Antimicrobial-loaded hydrogels are used as a dressing for infected wounds, but the ongoing rise in the number of antimicrobial-resistant infections necessitates new, nonantibiotic based designs. Here, a guanosine-quadruplex (G₄ )-hydrogel composed of guanosine, 2-formylphenylboronic acid, and putrescine is designed and used as a cascade-reaction container. The G₄ -hydrogel is loaded with glucose-oxidase and hemin. The first cascade-reaction, initiated by glucose-oxidase, transforms glucose and O₂  into gluconic acid and H₂ O₂ . In vitro, this reaction is most influential on killing Staphylococcus aureus or Pseudomonas aeruginosa in

SUBMITTER: Li Y 

PROVIDER: S-EPMC8895150 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature