Consistent Biofilm Formation by Streptococcus pyogenes emm 1 Isolated From Patients With Necrotizing Soft Tissue Infections.

ABSTRACT:

Objectives

Biofilm formation has been demonstrated in muscle and soft tissue samples from patients with necrotizing soft tissue infection (NSTI) caused by Streptococcus pyogenes, but the clinical importance of this observation is not clear. Although M-protein has been shown to be important for in vitro biofilm formation in S. pyogenes, the evidence for an association between emm type and biofilm forming capacity is conflicting. Here we characterize the biofilm forming capacity in a collection of S. pyogenes isolates causing NSTI, and relate this to emm type of the isolates and clinical characteristics of the patients.

Methods

Bacterial isolates and clinical data were obtained from NSTI patients enrolled in a multicenter prospective o

SUBMITTER: Skutlaberg DH 

PROVIDER: S-EPMC8895234 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature