Fragment-Based Drug Discovery by NMR. Where Are the Successes and Where can It Be Improved?

ABSTRACT: Over the last century, the definitions of pharmaceutical drug and drug discovery have changed considerably. Evolving from an almost exclusively serendipitous approach, drug discovery nowadays involves several distinct, yet sometimes interconnected stages aimed at obtaining molecules able to interact with a defined biomolecular target, and triggering a suitable biological response. At each of the stages, a wide range of techniques are typically employed to obtain the results required to move the project into the next stage. High Throughput Screening (HTS) and Fragment Based Drug Design (FBDD) are the two main approaches used to identify drug-like candidates in the early stages of drug discovery. Nuclear Magnetic Resonance (NMR) spectroscopy has many applications in FBDD and is used extensiv

SUBMITTER: Mureddu LG 

PROVIDER: S-EPMC8895297 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature