Role of Environment and Experimenter in Reproducibility of Behavioral Studies With Laboratory Mice.

ABSTRACT: Behavioral phenotyping of mice has received a great deal of attention during the past three decades. However, there is still a pressing need to understand the variability caused by environmental and biological factors, human interference, and poorly standardized experimental protocols. The inconsistency of results is often attributed to the inter-individual difference between the experimenters and environmental conditions. The present work aims to dissect the combined influence of the experimenter and the environment on the detection of behavioral traits in two inbred strains most commonly used in behavioral genetics due to their contrasting phenotypes, the C57BL/6J and DBA/2J mice. To this purpose, the elevated O-maze, the open field with object, the accelerating rotarod and the Barnes ma

SUBMITTER: Nigri M 

PROVIDER: S-EPMC8895324 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature