In vivo Measurements of Electric Fields During Cranial Electrical Stimulation in the Human Brain.

ABSTRACT: Cranial electrical stimulation (CES) has been applied at various current levels in both adults and children with neurological conditions with seemingly promising but somewhat inconsistent results. Stimulation-induced spatial electric fields (EFs) within a specific brain region are likely a significant contributing factor for the biological effects. Although several simulation models have been used to predict EF distributions in the brain, these models actually have not been validated by in vivo CES-induced EF measurements in the live human brain. This study directly measured the CES-induced voltage changes with implanted stereotactic-electroencephalographic (sEEG) electrodes in twenty-one epilepsy participants (16 adults and 5 children) and then compared these measured values with t

SUBMITTER: Wang M 

PROVIDER: S-EPMC8895368 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature