Solid-State Deracemization via Temperature Cycles in Continuous Operation: Model-Based Process Design.

ABSTRACT: Solid-state deracemization via temperature cycles converts a racemic crystal mixture into an enantiopure product by periodic cycling of the temperature in the presence of a racemization catalyst. A continuous counterpart of this conventional batch-operated process is proposed that can be performed in mixed suspension mixed product removal crystallizers (MSMPRCs). More specifically, three different configurations are described to perform periodic forcing via temperature cycles, which differ from each other in the type of the feed and in the withdrawal system. We have developed a model by extending our recent population balance equation model of batch solid-state deracemization via temperature cycles, and we exploit this tool to analyze the start-up and periodic steady-state behavior. Moreov

SUBMITTER: Bodak B 

PROVIDER: S-EPMC8895372 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature