Functionalizing silica sol-gel with entrapped plant virus-based immunosorbent nanoparticles.

ABSTRACT: Advancements in understanding and engineering of virus-based nanomaterials (VBNs) for biomedical applications motivate a need to explore the interfaces between VBNs and other biomedically-relevant chemistries and materials. While several strategies have been used to investigate some of these interfaces with promising initial results, including VBN-containing slow-release implants and VBN-activated bioceramic bone scaffolds, there remains a need to establish VBN-immobilized three dimensional materials that exhibit improved stability and diffusion characteristics for biosensing and other analyte-capture applications. Silica sol-gel chemistries have been researched for biomedical applications over several decades and are well understood; various cellular organisms and biomolecules (e.g., bact

SUBMITTER: McNulty MJ 

PROVIDER: S-EPMC8895542 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature