Extensive metagenomic analysis of the porcine gut resistome to identify indicators reflecting antimicrobial resistance.

ABSTRACT:

Background

Antimicrobial resistance (AMR) has been regarded as a major threat to global health. Pigs are considered an important source of antimicrobial resistance genes (ARGs). However, there is still a lack of large-scale quantitative data on the distribution of ARGs in the pig production industry. The bacterial species integrated ARGs in the gut microbiome have not been clarified.

Results

In the present study, we used deep metagenomic sequencing data of 451 samples from 425 pigs including wild boars, Tibetan pigs, and commercial or cross-bred experimental pigs under different rearing modes, to comprehensively survey the diversity and distribution of ARGs and detect the bacteria integrated in these ARGs. We identified a total of 1295 open reading frames (ORFs) recognized a

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC8895625 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature