Biomimetic radiosensitizers unlock radiogenetics for local interstitial radiotherapy to activate systematic immune responses and resist tumor metastasis.

ABSTRACT:

Background

Similar to other local therapeutic methods, local interstitial radiotherapy (IRT) also suffers from insufficient systematic immune activation, resulting in tumor metastasis.

Results

Mn-based IRT radiosensitizers consisting of ¹³¹I, MnO₂ and bovine serum albumin (BSA) (¹³¹I-MnO₂-BSA) were engineered. Such Mn-based IRT radiosensitizers successfully unlocked radiogenetics to magnify systematic immune responses of local IRT via remodeling hypoxic and immunosuppressive microenvironments and resist tumor metastasis. The MnO₂ in ¹³¹I-MnO₂-BSA caused decomposition of H₂O₂ enriched in tumors to generate O₂ for alleviating hypoxic microenvironment and removing tumor

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8895626 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature