Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson's disease.

ABSTRACT:

Background

The underlying pathophysiology of Parkinson's disease is complex, involving different molecular pathways, including brain iron deposition and mitochondrial dysfunction. At a molecular level, these disease mechanisms are likely interconnected. Therefore, they offer potential strategies for disease-modifying treatments. We aimed to investigate subcortical brain iron deposition as a potential predictor of the bioenergetic status in patients with idiopathic Parkinson's disease.

Methods

Thirty patients with idiopathic Parkinson's disease underwent multimodal MR imaging (T1, susceptibility-weighted imaging, SWI) and ³¹phosphorus magnetic resonance spectroscopy imaging. SWI contrast-to-noise ratios served as a measure for brain iron deposition in the putamen,

SUBMITTER: Prasuhn J 

PROVIDER: S-EPMC8895656 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature