An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation.

ABSTRACT: 3-Alkylpyridine alkaloids (3-APAs) isolated from the arctic sponge Haliclona viscosa are a promising group of bioactive marine alkaloids. However, due to limited bioavailability, investigations of their bioactivity have been hampered. Additionally, synthesis of a common intermediate requires the use of protecting groups and harsh conditions. In this work, we developed a simple and concise two-step route to nine different natural and synthetic haliclocyclins. These compounds displayed modest antibiotic activity against several Gram-positive bacterial strains.

SUBMITTER: Kaplan AR 

PROVIDER: S-EPMC8895759 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature