Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model.

ABSTRACT:

Background

Osteoarthritis is a degenerative disease of the knee that affects 250 million people worldwide. Due to the rising incidence of knee replacement and revision surgery, there is a need for a nonsurgical treatment to reduce pain and improve function in patients with knee osteoarthritis. Placental-derived allografts, such as an amniotic suspension allograft (ASA), provide growth factors and cytokines that could potentially modulate the inflammatory environment of osteoarthritis. The purpose of this study was to evaluate the efficacy of ASA in a rat medial meniscal tear (MMT) induced osteoarthritis model through histology, microCT, synovial fluid biomarkers, and behavioral testing.

Methods

Rats underwent MMT surgery at day - 7; at day 0, rats were injected with either A

SUBMITTER: Kimmerling KA 

PROVIDER: S-EPMC8895852 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature