Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is among the top 5 causes of mortality in the world and can develop as a consequence of genetic and/or environmental factors. Current efforts are focused on identifying early life insults and how these contribute to COPD development. In line with this, our study focuses on the influence of early life nicotine exposure and its potential impact on (a) lung pulmonary functions, and (b) elastase-induced emphysema in adulthood.

Methods

To address this hypothesis, we developed a model of 2 hits, delivered at different time points: mouse pups were first exposed to nicotine/placebo in utero and during lactation, and then subsequently received elastase/placebo at the age of 11 weeks. The effect of nicotine pretreatment and elast

SUBMITTER: Blaskovic S 

PROVIDER: S-EPMC8895880 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature