Alterations of gut fungal microbiota in patients with rheumatoid arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is a systemic autoimmune disease, in addition, gut microbiota plays an important role in the etiology of RA. However, our understanding of alterations to the gut fungal microbiota in Chinese population with RA is still limited.

Methods

Serum samples were obtained from 62 patients with RA, and 39 age- and gender-matched healthy controls (HCs). Fecal samples were obtained from 42 RA patients and 39 HCs. Fecal fungal microbiota targeting internal transcribed spacer region 2 (ITS2) rRNA genes was investigated using MiSeq sequencing, as well as their associations with some diagnostic biomarkers for RA.

Results

Our results showed that the fungal diversity did not alter in RA patients but taxonomic composition of the fecal fungal microbio

SUBMITTER: Sun X 

PROVIDER: S-EPMC8896017 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature