Variations of urinary N-acetyl-β-D-glucosaminidase levels and its performance in detecting acute kidney injury under different thyroid hormones levels: a prospectively recruited, observational study.

ABSTRACT:

Objective

Changes in thyroid function will be accompanied by changes in urinary N-acetyl-β-D-glucosaminidase (uNAG) levels. Therefore, whether thyroid hormones interfere the ability of uNAG in detecting acute kidney injury (AKI) has raised concern in patients with critical illness.

Design

A prospectively recruited, observational study was performed.

Setting

Adults admitted to the intensive care unit of a grade A tertiary hospital in China.

Participants

A total of 1919 critically ill patients were enrolled in the study.

Main outcome measures

To investigate the variations of the ability of uNAG to detect AKI in patients with critical illness under different thyroid hormones levels (differences in area under the curve (AUC) for uNAG diagnosis and prediction

SUBMITTER: Liang S 

PROVIDER: S-EPMC8896032 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature