Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies.

ABSTRACT:

Background

On the basis of efficacy in mouse tumor models, multiple CD137 (4-1BB) agonist agents are being preclinically and clinically developed. The costimulatory molecule CD137 is inducibly expressed as a transmembrane or as a soluble protein (sCD137). Moreover, the CD137 cytoplasmic signaling domain is a key part in approved chimeric antigen receptors (CARs). Reliable pharmacodynamic biomarkers for CD137 ligation and costimulation of T cells will facilitate clinical development of CD137 agonists in the clinic.

Methods

We used human and mouse CD8 T cells undergoing activation to measure CD137 transcription and protein expression levels determining both the membrane-bound and soluble forms. In tumor-bearing mice plasma sCD137 concentrations were monitored on treatment with

SUBMITTER: Glez-Vaz J 

PROVIDER: S-EPMC8896037 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature