Automated analysis of cortical volume loss predicts seizure outcomes after frontal lobectomy.

ABSTRACT:

Objective

Patients undergoing frontal lobectomy demonstrate lower seizure-freedom rates than patients undergoing temporal lobectomy and several other resective interventions. We attempted to utilize automated preoperative quantitative analysis of focal and global cortical volume loss to develop predictive volumetric indicators of seizure outcome after frontal lobectomy.

Methods

Ninety patients who underwent frontal lobectomy were stratified based on seizure freedom at a mean follow-up time of 3.5 (standard deviation [SD] 2.5) years. Automated quantitative analysis of cortical volume loss organized by distinct brain region and laterality was performed on preoperative T1-weighted magnetic resonance imaging (MRI) studies. Univariate statistical analysis was used to select poten

SUBMITTER: Whiting AC 

PROVIDER: S-EPMC8896091 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature