Changes of Intestinal Microflora in Colorectal Cancer Patients after Surgical Resection and Chemotherapy.

ABSTRACT:

Objective

The change of bacterial flora structure in colorectal cancer (CRC) patients after treatment is not clear. The aim of this study was to explore the change and function of intestinal microflora in CRC before and after treatment.

Method

The 16S conserved region V3+V4 of intestinal flora obtained from CRC patients was sequenced and analyzed. Alpha and beta diversity indices were used to analyze the abundance and structure of gut flora. FAPROTAX, BugBase, and Tax4Fun software were used to analyze the species phenotypes and Kyoto Encyclopedia of Genes and Genomes Ontology (KO) function pathways.

Results

Total abundance and structure of species in CRC patients were significantly increased compared with healthy people (control group) (P < 0.05), but there was

SUBMITTER: Huang R 

PROVIDER: S-EPMC8896156 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature