Ontology highlight
ABSTRACT:
SUBMITTER: Deng W
PROVIDER: S-EPMC8896157 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Deng Wenyi W Fan Wenjing W Tang Tingting T Wan Hengquan H Zhao Simin S Tan Yao Y Oware Kwabena Agyare KA Tan Jieqiong J Li Jiequn J Qu Shunlin S
Oxidative medicine and cellular longevity 20220224
Farnesoid X receptors (FXR) are bile acid receptors that play roles in lipid, glucose, and energy homeostasis. Synthetic FXR-specific agonists have been developed for treating nonalcoholic fatty liver disease (NAFLD) patients. However, the detailed mechanism remains unclear. To investigate the effects of FXR on NAFLD and the possible mechanism, FXR-null mice were fed either a normal or a high-fat diet. The FXR-null mice developed hepatomegaly, steatosis, accumulation of lipid droplets in liver c ...[more]