Predicting biochemical-recurrence-free survival using a three-metabolic-gene risk score model in prostate cancer patients.

ABSTRACT:

Background

Biochemical recurrence (BCR) after initial treatment, such as radical prostatectomy, is the most frequently adopted prognostic factor for patients who suffer from prostate cancer (PCa). In this study, we aimed to construct a prognostic model consisting of gene expression profiles to predict BCR-free survival.

Methods

We analyzed 70 metabolic pathways in 152 normal prostate samples and 494 PCa samples from the UCSC Xena dataset (training set) via gene set enrichment analysis (GSEA) to select BCR-related genes and constructed a BCR-related gene risk score (RS) model. We tested the power of our model using Kaplan-Meier (K-M) plots and receiver operator characteristic (ROC) curves. We performed univariate and multivariate analyses of RS using other clinicopathological

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC8896158 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature