Streptococcus mutans-associated bacteria in dental plaque of severe early childhood caries.

ABSTRACT:

Background

Streptococcus mutans (S. mutans) is a potential pathogenic bacteria of dental caries. However, the level of S. mutans is low in some children with severe early childhood caries (SECC).

Aim

To evaluate the effect of S. mutans level on dental microbiome and cariogenesis.

Methods

The oral microbiota was compared between caries-free group (CF) and SECC group.16S rRNA gene sequencing was used for S. mutans level bacterial community analysis. The candidate bacteria that were closely related with S. mutans abundance were identified and confirmed by absolute quantitative real-time PCR in clinical dental plaque samples from CF and SECC groups.

Results

Through in-depth analysis of dental plaque microorganism, Leptot

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8896182 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature