Controlling Mesenchyme Tissue Remodeling via Spatial Arrangement of Mechanical Constraints.

ABSTRACT: Tissue morphogenetic remodeling plays an important role in tissue repair and homeostasis and is often governed by mechanical stresses. In this study, we integrated an in vitro mesenchymal tissue experimental model with a volumetric contraction-based computational model to investigate how geometrical designs of tissue mechanical constraints affect the tissue remodeling processes. Both experimental data and simulation results verified that the standing posts resisted the bulk contraction of the tissues, leading to tissue thinning around the posts as gap extension and inward remodeling at the edges as tissue compaction. We changed the geometrical designs for the engineered mesenchymal tissues with different shapes of posts arrangements (triangle vs. square), different side lengths (6 m

SUBMITTER: Winston TS 

PROVIDER: S-EPMC8896258 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature