Pan-cancer analyses of pyroptosis with functional implications for prognosis and immunotherapy in cancer.

ABSTRACT:

Background

Programmed cell death is an active and orderly form of cell death regulated by intracellular genes that plays an important role in the normal occurrence and development of the immune system, and pyroptosis has been found to be involved in tumorigenesis and development. However, compressive analysis and biological regulation of pyroptosis genes are lacking in cancers.

Methods

Using data from The Cancer Genome Atlas, we established a score level model to quantify the pyroptosis level in cancer. Multiomics bioinformatic analyses were performed to assess pyroptosis-related molecular features and the effect of pyroptosis on immunotherapy in cancer.

Results

In the present study, we performed a comprehensive analysis of pyroptosis and its regulator genes in cancer

SUBMITTER: Liu A 

PROVIDER: S-EPMC8896277 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature