Capacity for consciousness under ketamine anaesthesia is selectively associated with activity in posteromedial cortex in rats.

ABSTRACT: It remains unclear how specific cortical regions contribute to the brain's overall capacity for consciousness. Clarifying this could help distinguish between theories of consciousness. Here, we investigate the association between markers of regionally specific (de)activation and the brain's overall capacity for consciousness. We recorded electroencephalographic responses to cortical electrical stimulation in six rats and computed Perturbational Complexity Index state-transition (PCI^ST), which has been extensively validated as an index of the capacity for consciousness in humans. We also estimated the balance between activation and inhibition of specific cortical areas with the ratio between high and low frequency power from spontaneous electroencephalographic activity at each el

SUBMITTER: Arena A 

PROVIDER: S-EPMC8896332 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature