Is Immune Suppression Involved in the Ischemic Stroke? A Study Based on Computational Biology.

ABSTRACT:

Objective

To identify the genetic mechanisms of immunosuppression-related genes implicated in ischemic stroke.

Background

A better understanding of immune-related genes (IGs) involved in the pathophysiology of ischemic stroke may help identify drug targets beneficial for immunomodulatory approaches and reducing stroke-induced immunosuppression complications.

Methods

Two datasets related to ischemic stroke were downloaded from the GEO database. Immunosuppression-associated genes were obtained from three databases (i.e., DisGeNET, HisgAtlas, and Drugbank). The CIBERSORT algorithm was used to calculate the mean proportions of 22 immune-infiltrating cells in the stroke samples. Differential gene expression analysis was performed to identify the differentially expressed ge

SUBMITTER: Wang X 

PROVIDER: S-EPMC8896355 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature