The Difference Between Cystatin C- and Creatinine-Based Estimated GFR and Associations With Frailty and Adverse Outcomes: A Cohort Analysis of the Systolic Blood Pressure Intervention Trial (SPRINT).

ABSTRACT:

Rationale & objective

In prior research and in practice, the difference between estimated glomerular filtration rate (eGFR) calculated from cystatin C level and eGFR calculated from creatinine level has not been assessed for clinical significance and relevance. We evaluated whether these differences contain important information about frailty.

Study design

A cohort analysis of the Systolic Blood Pressure Intervention Trial (SPRINT).

Setting & participants

9,092 hypertensive SPRINT participants who had baseline measurements of serum creatinine, cystatin C, and frailty.

Exposure

eGFRs calculated using CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equations (eGFR_cys and eGFR_cr), and eGFR_Diff, calculated as eGFR_cy

SUBMITTER: Potok OA 

PROVIDER: S-EPMC8896529 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature