CD71⁺ Erythroid Cell Expansion in Adult Sepsis: Potential Causes and Role in Prognosis and Nosocomial Infection Prediction.

ABSTRACT:

Background

Immune suppression contributes to nosocomial infections (NIs) and poor prognosis in sepsis. Recent studies revealed that CD71⁺ erythroid cells had unappreciated immunosuppressive functions. This study aimed to investigate the values of CD71⁺ erythroid cells (CECs) in predicting NIs and prognosis among adult septic patients. The potential factors associated with the expansion of CECs were also explored.

Methods

In total, 112 septic patients and 32 critically ill controls were enrolled. The frequencies of CD71⁺ cells, CD71⁺CD235a⁺ cells, and CD45⁺ CECs were measured by flow cytometry. The associations between CECs and NIs and 30-day mortality were assessed by ROC curve analysis and Cox and competing-r

SUBMITTER: Zhao GJ 

PROVIDER: S-EPMC8896534 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature