Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity.

ABSTRACT:

Background

Neutrophils are involved in the initial host responses to pathogens. Neutrophils can activate T cell responses either independently or through indirect involvement of Dendritic cells (DCs). Recently we have demonstrated direct neutrophil-T cell interactions that initiate adaptive immune responses following immunization with live attenuated Leishmania donovani centrin deleted parasite vaccine (LdCen-/-). However, neutrophil-DC interactions in T cell priming in vaccine immunity in general are not known. In this study we evaluated the interaction between neutrophils and DCs during LdCen-/- infection and compared with wild type parasite (LdWT) both in vitro and in vivo.

Methodology/findings

LdCen-/- parasite induced increased expression of CCL3 in neutrophils caused h

SUBMITTER: Bhattacharya P 

PROVIDER: S-EPMC8896671 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature