Drug delivery from a solid formulation during breastfeeding-A feasibility study with mothers and infants.

ABSTRACT:

Background

Breastfeeding is critical to health outcomes, particularly in low-resource settings where there is little access to clean water. For infants in their first twelve months of life, the delivery of medications is challenging, and use of oral syringes to deliver liquid formulations can pose both practical and emotional challenges.

Objective

To explore the potential to deliver medicine to infants via a solid formulation during breastfeeding.

Methods

Single center feasibility study within a tertiary level neonatal unit in the UK, involving twenty-six breastfeeding mother-infant dyads. A solid formulation of Vitamin B12 was delivered to infants during breastfeeding. Outcomes included the quantitative change in serum vitamin B12 and assessment of maternal expectati

SUBMITTER: Maier T 

PROVIDER: S-EPMC8896718 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature