TNF-α levels and presence of SNP-308G/A of TNF-α gene in temporomandibular disorder patients.

ABSTRACT:

Introduction

Temporomandibular disorder (TMD) refers to a group of conditions that compromise the harmonious movement and function of the temporomandibular joint, masticatory muscles, and associated structures. The etiopathogenesis of TMD is multifactorial but not well-understood, with the role of genetic factors still being unclear.

Objective

This review aims to summarize the results of studies that evaluated TNF-α levels and the -308G/A TNF-α polymorphism in TMD patients. This study emphasizes the importance of a more selective treatment involving TNF-α inhibitors that can potentially reduce inflammation and pain, and improve quality of life.

Methods

The MEDLINE/PubMed database, Cochrane Library, and Web of Science database were searched for case-control studies pub

SUBMITTER: Campello CP 

PROVIDER: S-EPMC8896744 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature