The vaginal microbiota, high-risk human papillomavirus infection, and cervical cytology: results from a population-based study.

ABSTRACT:

Background

The relationship between the vaginal microbiota, high-risk human papillomavirus infection, and abnormal cervical cytology has not been well characterized. Our objective was to characterize the vaginal microbiota in a stratified random sample of women from a population-based study in Appalachia.

Methods

We analyzed a random sample of 308 women in the Community Access, Resources and Education: Project 3 study across 16 clinics in Ohio and West Virginia. Using Illumina MiSeq sequencing of 16S rRNA gene amplicons, we characterized the vaginal microbiota among (I) 109 women randomly chosen with abnormal cervical cytology (i.e., the majority were atypical squamous cells of undetermined significance (n=55) and low-grade squamous intraepithelial lesions (n=45) while n=6 w

SUBMITTER: McKee KS 

PROVIDER: S-EPMC8896808 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature